Epoprostenol

Cat. No. 2989

Epoprostenol C20H31NaO5 [61849-14-7]

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Alternative Names: Prostaglandin I2, Prostacyclin

Chemical Name: (5Z,13E,8R,9S,11R,12R,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt

Biological Activity

Endogenous prostanoid that is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.

Technical Data

M.Wt:
374.45
Formula:
C20H31NaO5
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -80°C
CAS No:
61849-14-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kobzar et al (2001) Comparison of anti-aggregatory effects of PGI2, PGI3 and iloprost on human and rabbit platelets. Cell.Physiol.Biochem. 11 279. PMID: 11684817.

Oliva and Nicosia (1987) PGI2-receptors and molecular mechanisms in platelets and vasculature: state of the art. Pharmacol.Res.Comm. 19 735.

If you know of a relevant reference for Epoprostenol please let us know.

Citations are publications that use Tocris products. Selected citations for Epoprostenol include:

Armstrong et al (2015) Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. Blood 126 e11. PMID: 26215112.

Do you know of a great paper that uses Epoprostenol from Tocris? If so please let us know.

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Keywords: Epoprostenol, supplier, Endogenous, IP, receptors, agonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, Tocris Bioscience, Prostanoid Receptor Agonist products

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