2-Methoxyestradiol

Cat. No. 1807

2-Methoxyestradiol C19H26O3 [362-07-2]

Price and Availability

For 2-Methoxyestradiol pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol

Biological Activity

Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

Technical Data

M.Wt:
302.41
Formula:
C19H26O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
362-07-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

LaVallee et al (2003) 2-Methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 63 468. PMID: 12543804.

Shimada et al (2003) Roles of p38 and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24 1067. PMID: 12807754.

LaVallee et al (2002) 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res. 62 3691. PMID: 12097276.

D'Amato et al (1994) 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc.Natl.Acad.Sci.U.S.A. 91 3964. PMID: 8171020.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses 2-Methoxyestradiol from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: 2-Methoxyestradiol, supplier, Apoptotic, agent, Apoptosis, Inducer, Antiangiogenics, Tocris Bioscience, Apoptosis Inducing products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

divider line

Apoptosis Pathway

Apoptosis Signaling Pathway

Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.