SR 2640 hydrochloride
Cat. No. 1804
Chemical Name: 2-[[3-(2-Quinolinylmethoxy)phenyl]a
Biological ActivityPotent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4-attenuation of human PMN chemotaxis. Orally active in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bouchelouche et al (1990) LTD4 increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD4 receptor antagonist, SR2640, and possible relation to modulation of chemotaxis. Agents Actions 29 299. PMID: 2160189.
Thomsen and Ahnfelt-Ronne (1989) Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions. Biochem.Pharmacol. 38 2291. PMID: 2546563.
Ahnfelt-Ronne et al (1988) A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur.J.Pharmacol. 155 117. PMID: 2854067.
If you know of a relevant reference for SR 2640 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SR 2640 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SR 2640 hydrochloride, supplier, Potent, selective, LTD4, /LTE4, receptors, antagonists, leukotrienes, eicosanoids, SR2640, hydrochloride, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Highly potent P2Y12 antagonistFTY 720
Potent S1P receptor agonist; also immunosuppressantCinacalcet hydrochloride
Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailableAMG 837 hemicalcium salt
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligandAZD 1283
High affinity P2Y12 antagonistEx 26
Potent and selective S1P1 receptor antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.