SR 2640 hydrochloride

Cat. No. 1804

SR 2640 hydrochloride C23H18N2O3.HCl [146662-42-2]

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Chemical Name: 2-[[3-(2-Quinolinylmethoxy)phenyl]amino]benzoic acid hydrochloride

Biological Activity

Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4-attenuation of human PMN chemotaxis. Orally active in vivo.

Technical Data

M.Wt:
406.87
Formula:
C23H18N2O3.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
146662-42-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bouchelouche et al (1990) LTD4 increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD4 receptor antagonist, SR2640, and possible relation to modulation of chemotaxis. Agents Actions 29 299. PMID: 2160189.

Thomsen and Ahnfelt-Ronne (1989) Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions. Biochem.Pharmacol. 38 2291. PMID: 2546563.

Ahnfelt-Ronne et al (1988) A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur.J.Pharmacol. 155 117. PMID: 2854067.

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Keywords: SR 2640 hydrochloride, supplier, Potent, selective, LTD4, /LTE4, receptors, antagonists, leukotrienes, eicosanoids, SR2640, hydrochloride, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products

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