Cat. No. 1803

ITE C14H10N2O3S [448906-42-1]

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Alternative Name: Aryl hydrocarbon receptor ligand

Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester

Biological Activity

Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.

Licensing Information

Sold under license, US Patent Application 2002183524

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Cheng et al (2015) Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat.Commun. 6 7209. PMID: 26059097.

Wang et al (2013) An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett. 340 63. PMID: 23851185.

Lehmann et al (2011) The aryl hydrocarbon receptor ligand ITE inhibits TGF1-induced human myofibroblast differentiation. Am.J.Pathol. 178 1556. PMID: 21406171.

Song et al (2002) A ligand for the aryl hydrocarbon receptor isolated from lung. Proc.Natl.Acad.Sci.U.S.A. 99 14694. PMID: 12409613.

If you know of a relevant reference for ITE please let us know.

Citations are publications that use Tocris products. Selected citations for ITE include:

Wu et al (2014) ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR. PLoS One 9 e86549. PMID: 24475139.

Nugent et al (2013) ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity. PLoS One 54 7463. PMID: 24150760.

Wang et al (2013) An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett 340 63. PMID: 23851185.

Yeste et al (2012) Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 109 11270. PMID: 22745170.

Do you know of a great paper that uses ITE from Tocris? If so please let us all ▼show less ▲

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Keywords: ITE, supplier, Endogenous, agonists, transcription, factor, aryl, hydrocarbon, receptor, AHR, Receptors, myofibroblast, differentiation, inhibits, inhibitors, stem, cells, stem-like, cancer, Tocris Bioscience, Aryl Hydrocarbon Receptor Agonist products

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