WAY 161503 hydrochloride

Cat. No. 1801

WAY 161503 hydrochloride C11H11Cl2N3O.HCl [276695-22-8]

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Chemical Name: 8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride

Biological Activity

Potent and selective 5-HT2C receptor agonist (Ki = 4 nM; EC50 = 12 nM). Antidepressant following systemic administration in vivo.

Technical Data

M.Wt:
308.59
Formula:
C11H11Cl2N3O.HCl
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
276695-22-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive properties. J.Med.Chem. 56 1211. PMID: 23301527.

Cryan and Lucki (2000) Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine2C receptors. J.Pharmacol.Exp.Ther. 295 1120. PMID: 11082448.

Welmaker et al (2000) Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg.Med.Chem.Lett. 10 1991. PMID: 10987434.

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Citations are publications that use Tocris products. Selected citations for WAY 161503 hydrochloride include:

Doslikova et al (2013) 5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated. J Neurosci 33 9800. PMID: 23739976.

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Keywords: WAY 161503 hydrochloride, supplier, Potent, selective, 5-HT2C, agonists, Serotonin, Receptors, WAY161503, hydrochloride, Tocris Bioscience, 5-HT2C Receptor Agonist products

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