Cat. No. 1799
Alternative Name: W-peptide
Biological ActivitySelective agonist for the formyl peptide receptors FPR2 and FPR3, expressed on immune cells. EC50 values for induction of calcium mobilization in FPR2-HL-60 cells and FPR3-HL-60 cells are 2 and 80 nM respectively.
(Modifications: Met-6 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Christophe et al (2002) Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1 /LXA4R, is not affected by lipoxin. Scand.J.Immunol. 56 470. PMID: 12410796.
Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585. PMID: 11285256.
Baek et al (1996) Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries. J.Biol.Chem. 271 8170. PMID: 8626507.
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Citations are publications that use Tocris products. Selected citations for WKYMVM include:
Schepetkin et al (2014) Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones. Biochem Pharmacol 92 627. PMID: 25450672.
Schepetkin et al (2013) 3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2. Biochem Pharmacol 85 404. PMID: 23219934.
Schepetkin et al (2011) Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol Pharmacol 79 77. PMID: 20943772.
Do you know of a great paper that uses WKYMVM from Tocris? If so please let us know.
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Keywords: WKYMVM, supplier, Selective, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, Tocris Bioscience, Formyl Peptide Receptor Agonist products
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November 12 - 16, 2016
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