Gabexate mesylate

Cat. No. 1798

Gabexate mesylate C16H23N3O4.CH3SO3H [56974-61-9]

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Alternative Name: FOY

Chemical Name: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate

Biological Activity

Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation.

Technical Data

M.Wt:
417.48
Formula:
C16H23N3O4.CH3SO3H
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
56974-61-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yuksel et al (2003) Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes. J.Pharmacol.Exp.Ther. 305 298. PMID: 12649382.

Ohno et al (1981) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulo-fibrinolytic system in comparison with heparin or aprotinin. Thromb.Res. 24 445. PMID: 6178174.

Ohno et al (1980) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb.Res. 19 579. PMID: 6449757.

Tamura et al (1977) Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r and C1 esterase. Biochim.Biophys.Acta 484 417. PMID: 143965.

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Keywords: Gabexate mesylate, supplier, Serine, protease, inhibits, inhibitors, thrombin, trypsin, kallikrein, plasmin, TNF-α, TNF-alpha, production, antithrombotic, agent, Proteases, Proteinases, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, PAR, Receptors, Protease-Activated, proteinase-activated, Tocris Bioscience, Protease-Activated Receptor Inhibitor products

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