Cat. No. 1798
Alternative Name: FOY
Chemical Name: 4-[[6-[(Aminoiminomethyl)amino]-1-o
Biological ActivitySerine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Yuksel et al (2003) Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes. J.Pharmacol.Exp.Ther. 305 298. PMID: 12649382.
Ohno et al (1981) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulo-fibrinolytic system in comparison with heparin or aprotinin. Thromb.Res. 24 445. PMID: 6178174.
Ohno et al (1980) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb.Res. 19 579. PMID: 6449757.
Tamura et al (1977) Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r and C1 esterase. Biochim.Biophys.Acta 484 417. PMID: 143965.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Gabexate mesylate from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Gabexate mesylate, supplier, Serine, protease, inhibits, inhibitors, thrombin, trypsin, kallikrein, plasmin, TNF-α, TNF-alpha, production, antithrombotic, agent, Proteases, Proteinases, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, PAR, Receptors, Protease-Activated, proteinase-activated, Tocris Bioscience, Protease-Activated Receptor Inhibitor products
Find multiple products by catalog number
New Products in this Area
Non-peptide apelin receptor agonistBML 111
FPR2 (lipoxin A4 receptor) agonistAmylin (rat)
Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptorsCalcitonin (human)
Endogenous calcitonin receptor agonist; inhibits bone resorptionSpexin
Potent GAL2/3 agonist; exhibits anxiolytic effects in vivoMM 54
Potent apelin receptor antagonist
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for ISSCR 2017.