Zacopride hydrochloride

Cat. No. 1795

Zacopride hydrochloride C15H20ClN3O2.HCl [101303-98-4]

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Chemical Name: (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride

Biological Activity

Highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). Antiemetic and anxiolytic following systemic administration in vivo.

Technical Data

M.Wt:
346.26
Formula:
C15H20ClN3O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
101303-98-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Nagakura et al (1999) Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Pharmacol.Res. 39 375. PMID: 10328995.

Kii and Ito (1997) Effects of 5-HT4-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles. J.Cardiovasc.Pharmacol. 29 670. PMID: 9213211.

Cohen et al (1989) Comparison of the 5-HT3 receptor antagonist properties of ICS 205-930, GR38032F and zacopride. J.Pharmacol.Exp.Ther. 248 197. PMID: 2521513.

Costall et al (1988) Zacopride: anxiolytic profile in rodent and primate models of anxiety. J.Pharm.Pharmacol. 40 302. PMID: 2900320.

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Keywords: Zacopride hydrochloride, supplier, 5-HT4, agonists, potent, 5-HT3, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, Tocris Bioscience, 5-HT3 Receptor Antagonist products

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Written by N. Barnes & J. Neumaler

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