Ro 26-4550 trifluoroacetate
Cat. No. 1794
Chemical Name: N-[[(3R)-1-(Aminoiminomethyl)-3-pip
Biological ActivityCompetitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Braisted et al (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 125 3714. PMID: 12656598.
Tilley et al (1997) Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc. 119 7589.
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Keywords: Ro 26-4550 trifluoroacetate, supplier, Competitive, inhibitors, inhibits, IL-2/, IL-2Ralpha, interaction, IL, Receptors, Interleukins, Cytokines, Ro26-4550, Tocris Bioscience, Cytokine Receptor products
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