AF 12198

Cat. No. 1793

AF 12198 Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2

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Biological Activity

Potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo.

Technical Data

M.Wt:
1895.14
Formula:
C96H123N19O22
Sequence:
FEWTPGWYQXYALPL

(Modifications: Phe-1 = N-terminal Ac, X - Aze, Leu-15 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 10% ethanol/PBS
Storage:
Desiccate at -20°C
CAS No:
185413-30-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Aimbire et al (2008) Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1β levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation 31 189. PMID: 18421573.

Akeson et al (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J.Biol.Chem. 271 30517. PMID: 8940020.

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Citations are publications that use Tocris products. Selected citations for AF 12198 include:

Lin et al (2010) Interleukin-1β expression is required for lysophosphatidic Acid-induced lymphangiogenesis in human umbilical vein endothelial cells. J Psychopharmacol 2011 351010. PMID: 21151531.

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Keywords: AF 12198, supplier, Potent, selective, human, type, I, IL-1, receptors, antagonists, IL, Interleukins, Cytokines, AF12198, Tocris Bioscience, Cytokine Receptor Antagonist products

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