PKC β pseudosubstrate

Cat. No. 1792

PKC b pseudosubstrate H-Cys-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH H-Cys-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-OH (Disulfide bridge: 17 -1*)

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Alternative Name: Protein kinase C beta pseudosubstrate

Biological Activity

Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.

Technical Data

M.Wt:
3994.84
Formula:
C177H294N62O38S3
Sequence:
CRQIKIWFQNRRMKWKK CRFARKGALRQKNV*

(Modifications: Disulfide bridge between 17 -1*)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
172308-76-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

References are publications that support the products' biological activity.

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158. PMID: 7472470.

Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 269 10444. PMID: 8144628.

House and Kemp (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 1726. PMID: 3686012.

If you know of a relevant reference for PKC β pseudosubstrate please let us know.

Citations are publications that use Tocris products.

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Keywords: PKC b pseudosubstrate, supplier, Selective, cell-permeable, PKC, inhibitors, inhibits, Protein, Kinases, C, beta, pseudosubstrate, PKCb, Tocris Bioscience, Protein Kinase C Inhibitor products

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