PKC β pseudosubstrate
Cat. No. 1792
Alternative Name: Protein kinase C beta pseudosubstrate
Biological ActivitySelective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.
(Modifications: Disulfide bridge between 17 -1*)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
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Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158. PMID: 7472470.
Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 269 10444. PMID: 8144628.
House and Kemp (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 1726. PMID: 3686012.
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Keywords: PKC b pseudosubstrate, supplier, Selective, cell-permeable, PKC, inhibitors, inhibits, Protein, Kinases, C, beta, pseudosubstrate, PKCb, Tocris Bioscience, Protein Kinase C Inhibitor products
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