PKC ζ pseudosubstrate

Cat. No. 1791

PKC z pseudosubstrate H-Cys-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH H-Cys-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-Tyr-Arg-Ala-Asn-OH

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Alternative Name: Protein kinase C zeta pseudosubstrate

Biological Activity

Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.

Technical Data

M.Wt:
4673.59
Formula:
C208H336N74O44S3
Sequence:
CRQIKIWFQNRRMKWKK CSIYRRGARRWRKLYRAN*

(Modifications: Disulfide bridge between 1 -1*)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lim et al (2008) A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity. Life Sci. 82 733. PMID: 18289606.

Laudanna et al (1998) Evidence of ζ protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J.Biol.Chem 273 30306. PMID: 9804792.

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158. PMID: 7472470.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PKC ζ pseudosubstrate include:

Mu et al (2011) TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nat Commun 2 330. PMID: 21629263.

Do you know of a great paper that uses PKC ζ pseudosubstrate from Tocris? If so please let us know.

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Keywords: PKC z pseudosubstrate, supplier, PKC, zeta, inhibitors, inhibits, Protein, Kinases, C, pseudosubstrate, PKCz, ProteinkinaseC, Tocris Bioscience, Protein Kinase C Inhibitor products

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