Pseudo RACK1

Cat. No. 1790

Pseudo RACK1 H-Cys-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH NH2-Cys-Ser-Val-Glu-Ile-Trp-Asp-OH (Disulfide bridge: 17 -1*)

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Biological Activity

Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.

Technical Data

M.Wt:
3198.81
Formula:
C144H225N43O34S3
Sequence:
KKWKMRRNQFWIKIQRC CSVEIWD*

(Modifcations: Disulfide bridge between 17 -1*)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ron and Mochly-Rosen (1995) An autoregulatory region in protein kinase C: the pseudoanchoring site. Proc.Natl.Acad.Sci.U.S.A. 92 492. PMID: 7831317.

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158. PMID: 7472470.

Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 269 10444. PMID: 8144628.

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Keywords: Pseudo RACK1, supplier, Protein, kinases, C, activators, PKC, Tocris Bioscience, Protein Kinase C Activator products

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