GRP (human)

Cat. No. 1789

GRP (human) Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2

Price and Availability

For GRP (human) pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Gastrin-releasing peptide (human)

Biological Activity

Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.

Technical Data

M.Wt:
2859.4
Formula:
C130H204N38O31S2
Sequence:
VPLPAGGGTVLTKMYPRGNHWAVGHLM

(Modifications: Met-27 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
93755-85-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dudai (2003) Neurobiology: Fear thou not. Nature 421 325. PMID: 12540884.

Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905. PMID: 12526815.

Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 780 223. PMID: 8602736.

Benya et al (1995) Expression and characterization of cloned human bombesin receptors. Mol.Pharmacol. 47 10. PMID: 7838118.

If you know of a relevant reference for GRP (human) please let us know.

Citations are publications that use Tocris products. Selected citations for GRP (human) include:

Blais et al (2016) Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin Neuroscience Letters 633 262. PMID: 27693662.

Lee and Ko (2015) Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Int J Inflam 5 11676. PMID: 26119696.

Solorzano et al (2015) Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. Sci Rep 35 648. PMID: 25589759.

Kim et al (2013) Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells. J Neurosci 9 1579. PMID: 24108003.

Do you know of a great paper that uses GRP (human) from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Target

View Related Products by Product Action

Keywords: GRP (human), supplier, Endogenous, GRP, receptor, agonists, GRP-Preferring, Receptors, BB2, Gastrin-Releasing, Peptide-Preferring, Bombesin, Tocris Bioscience, Bombesin Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Appetite Modulation

Written by S. Tucci et al

Peptides Involved in Appetite Modulation Scientific Review

Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis. View PDF today.

divider line

New Products in this Area

Retrobradykinin

Reverse analog of Bradykinin

TASP 0390325

Potent and selective V1B receptor antagonist; orally bioavailable

ML 233

Non-peptide apelin receptor agonist

BML 111

FPR2 (lipoxin A4 receptor) agonist

Amylin (rat)

Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors

Calcitonin (human)

Endogenous calcitonin receptor agonist; inhibits bone resorption

Sign-up for new product e-alerts
divider line

Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennal Meeting

August 20 - 24, 2017

Paris , France