Cat. No. 1789
Alternative Name: Gastrin-releasing peptide (human)
Biological ActivityMammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
(Modifications: Met-27 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Dudai (2003) Neurobiology: Fear thou not. Nature 421 325. PMID: 12540884.
Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905. PMID: 12526815.
Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 780 223. PMID: 8602736.
Benya et al (1995) Expression and characterization of cloned human bombesin receptors. Mol.Pharmacol. 47 10. PMID: 7838118.
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Citations are publications that use Tocris products. Selected citations for GRP (human) include:
Lee and Ko (2015) Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Int J Inflam 5 11676. PMID: 26119696.
Solorzano et al (2015) Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. Sci Rep 35 648. PMID: 25589759.
Kim et al (2013) Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells. J Neurosci 9 1579. PMID: 24108003.
Do you know of a great paper that uses GRP (human) from Tocris? If so please let us know.
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Keywords: GRP (human), supplier, Endogenous, GRP, receptor, agonists, GRP-Preferring, Receptors, BB2, Gastrin-Releasing, Peptide-Preferring, Bombesin, Tocris Bioscience, Bombesin Receptor Agonist products
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