GRP (porcine)

Cat. No. 1788

GRP (porcine) Ala-Pro-Val-Ser-Val-Gly-Gly-Gly-Thr-Val-Leu-Ala-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2

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Alternative Name: Gastrin-releasing peptide (porcine)

Biological Activity

Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.

Technical Data

M.Wt:
2805.31
Formula:
C126H198N38O31S2
Sequence:
APVSVGGGTVLAKMYPRGNHWAVGHLM

(Modifications: Met-27 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
74815-57-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Dudai (2003) Neurobiology: Fear thou not. Nature 421 325. PMID: 12540884.

Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905. PMID: 12526815.

Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 780 223. PMID: 8602736.

Schjoldager et al (1991) Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction. Am.J.Physiol. 260 G577. PMID: 1708207.

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Keywords: GRP (porcine), supplier, Endogenous, GRP, receptor, agonists, GRP-Preferring, Receptors, BB2, Gastrin-Releasing, Peptide-Preferring, Bombesin, Tocris Bioscience, Bombesin Receptor Agonist products

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