Bax inhibitor peptide V5

Cat. No. 1785

Bax inhibitor peptide V5 Val-Pro-Met-Leu-Lys

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Biological Activity

Cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation. Designed based on the Bax-binding domain of human Ku70. Inhibits Bax-mediated apoptosis in vitro. Shown to inhibit anti-cancer drug-induced apoptosis in vitro. Negative control (Cat. No. 1787) available.

Licensing Information

Sold under license

Technical Data

M.Wt:
586.79
Formula:
C27H50N6O6S
Sequence:
VPMLK
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
579492-81-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Sawatzky et al (2006) The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. Am.J.Pathol. 168 33. PMID: 16400007.

Yoshida et al (2004) Bax-inhibiting peptide derived from mouse and rat Ku70. Biochem.Biophys.Res.Commun. 321 961. PMID: 15358121.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Bax inhibitor peptide V5 include:

Lee et al (2010) Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells. J Cell Sci 123 1634. PMID: 20406888.

Do you know of a great paper that uses Bax inhibitor peptide V5 from Tocris? If so please let us know.

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Keywords: Bax inhibitor peptide V5, supplier, inhibitors, inhibits, Bax-mediated, apoptosis, Bcl-XL, Mcl-1, Bcl-2, Family, Bax, inhibitor, peptideV5, Tocris Bioscience, Bcl-2 Family Inhibitor products

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