Zoniporide dihydrochloride

Cat. No. 2727

Zoniporide dihydrochloride C17H16N6O.2HCl [241799-10-0]

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Alternative Name: CP 597396

Chemical Name: [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride

Biological Activity

Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Technical Data

Soluble to 10 mM in water and to 100 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Clements-Jewery et al (2004) Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform-1, in an experimental model of cardiopulmonary bypass. Br.J.Pharmacol. 142 57. PMID: 15037516.

Marala et al (2002) Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1. Eur.J.Pharmacol. 451 37. PMID: 12223226.

Knight et al (2001) A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 297 254. PMID: 11259552.

If you know of a relevant reference for Zoniporide dihydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Zoniporide dihydrochloride include:

Féraille et al (2014) NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity. PLoS One 9 e87239. PMID: 24466344.

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Keywords: Zoniporide dihydrochloride, supplier, Selective, NHE-1, inhibitors, inhibits, Ion, Pumps, Transporters, Sodium-hydrogen, exchanger, isoform-1, CP597396, Tocris Bioscience, Na+/H+ Exchanger Inhibitor products

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