Cat. No. 2913
Chemical Name: (Z)-1-[2-Cycloheptyloxy-2-(2,6-dich
Biological ActivitySelective, non-competitive mGlu2 antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Brauner-Osbourne et al (2007) Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr.Drug Targets. 8 169. PMID: 17266540.
Kolczewski et al (1999) Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 9 2173. PMID: 10465539.
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Keywords: Ro 64-5229, supplier, Ro64-5229, mGluR2, mGlu2, group, II, metabotropic, glutamate, receptor, antagonist, antagonists, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Antagonist products
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