Cat. No. 2913
Chemical Name: (Z)-1-[2-Cycloheptyloxy-2-(2,6-dich
Biological ActivitySelective, non-competitive mGlu2 antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Brauner-Osbourne et al (2007) Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr.Drug Targets. 8 169. PMID: 17266540.
Kolczewski et al (1999) Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 9 2173. PMID: 10465539.
If you know of a relevant reference for Ro 64-5229 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Ro 64-5229 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ro 64-5229, supplier, Ro64-5229, mGluR2, mGlu2, group, II, metabotropic, glutamate, receptor, antagonist, antagonists, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Selective mGlu2 receptor positive allosteric modulator
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.