17-DMAG hydrochloride

Cat. No. 2610

17-DMAG hydrochloride C32H48N4O8.HCl [467214-21-7]

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Alternative Name: NSC 707545

Chemical Name: 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride

Biological Activity

Water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Licensing Information

Sold with the permission of the NIH, US Patent 6,890,917

Technical Data

M.Wt:
653.21
Formula:
C32H48N4O8.HCl
Solubility:
Soluble to 30 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
467214-21-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Dote et al (2006) Inhibition of Hsp90 compromises the DNA damage response to radiation. Cancer Res. 66 9211. PMID: 16982765.

Smith et al (2005) Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. Cancer Chemother.Pharmacol. 56 126. PMID: 15841378.

Egorin et al (2002) Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and fischer 344 rats. Cancer Chemother.Pharmacol. 49 7. PMID: 11855755.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 17-DMAG hydrochloride include:

Young et al (2015) A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Mol Med 11 113. PMID: 25700737.

Do you know of a great paper that uses 17-DMAG hydrochloride from Tocris? If so please let us know.

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Keywords: 17-DMAG hydrochloride, supplier, Water-soluble, Hsp90, inhibitors, inhibits, Heat, Shock, Protein, 90, NSC707545, antibiotics, Tocris Bioscience, Hsp90 Inhibitor products

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