Cat. No. 2790
Chemical Name: (2S)-1-[[[4-Methyl-1-(2-pyrimidinyl
Biological ActivityDipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Takasaki et al (2004) K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent. Eur.J.Pharmacol. 486 335. PMID: 14985056.
Takasaki et al (2004) Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats. J.Pharmacol.Sci. 95 291. PMID: 15215655.
Takasaki et al (2004) Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV. Eur.J.Pharmacol. 505 237. PMID: 15556158.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for K 579 include:
Fujiwara et al (2015) Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration. Arterioscler Thromb Vasc Biol 56 155. PMID: 25759522.
Do you know of a great paper that uses K 579 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: K 579, supplier, Dipeptidyl, peptidase, IV, DPP-IV, inhibitors, inhibits, Peptidase, Proteinases, Proteases, K579, Tocris Bioscience, Dipeptidyl Peptidase IV Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitorAcein
High affinity angiotensin-converting enzyme (ACE) ligandTMI 1
Adam 17 (TACE) and MMP inhibitor; orally bioavailableRitonavir
HIV-1 and HIV-2 protease inhibitorAcetyl Pepstatin
High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.