Spantide I

Cat. No. 1784

Spantide I D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2

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Alternative Name: [D-Arg1,D-Trp7,9,Leu11]-Substance P

Biological Activity

Selective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo.

Technical Data


(Modifications: Arg-1 = D-Arg, Trp-7 = Trp-9 = D-Trp)

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Zubrzycka et al (2000) Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr.Regul. 34 13. PMID: 10808247.

Beaujouan et al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793. PMID: 7682138.

Folkers et al (1984) Biological evaluation of substance P antagonists. Br.J.Pharmacol. 83 449. PMID: 6207886.

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Citations are publications that use Tocris products.

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Keywords: Spantide I, supplier, Selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, SpantideI, [D-Arg1, D-Trp7, 9, Leu11]-SubstanceP, Tocris Bioscience, NK1 Receptor Antagonist products

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