Cat. No. 1784
Alternative Name: [D-Arg1,D-Trp7,9,Leu11]-Substance P
Biological ActivitySelective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo.
(Modifications: Arg-1 = D-Arg, Trp-7 = Trp-9 = D-Trp)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Zubrzycka et al (2000) Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr.Regul. 34 13. PMID: 10808247.
Beaujouan et al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793. PMID: 7682138.
Folkers et al (1984) Biological evaluation of substance P antagonists. Br.J.Pharmacol. 83 449. PMID: 6207886.
If you know of a relevant reference for Spantide I please let us know.
Citations are publications that use Tocris products.
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Keywords: Spantide I, supplier, Selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, SpantideI, [D-Arg1, D-Trp7, 9, Leu11]-SubstanceP, Tocris Bioscience, NK1 Receptor Antagonist products
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