(R)-(+)-Methanandamide (in Tocrisolve™ 100)
Cat. No. 1782
Chemical Name: (R)-N-(2-Hydroxy-1-methylethyl)-5Z,
Biological ActivityStable anandamide analog that is a selective agonist for the CB1 receptor (Ki values are 20 and 815 nM for CB1 and CB2 receptors respectively), in water-soluble emulsion (for details see TocrisolveTM 100, Cat. No. 1684). Displays agonist activity at vanilloid receptors. (R)-(+)-Methanandamide also available as pure oil dissolved in ethanol (Cat. No. 1121).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Zygmunt et al (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400 452. PMID: 10440374.
Carriero et al (1998) A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing. Psychopharmacology (Berl.) 137 147. PMID: 9630001.
Khanolkar et al (1996) Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J.Med.Chem. 39 4515. PMID: 8893848.
Abadji et al (1994) (R)-Methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J.Med.Chem. 37 1889. PMID: 8021930.
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Citations are publications that use Tocris products. Selected citations for (R)-(+)-Methanandamide (in Tocrisolve™ 100) include:
Grace et al (2014) Identification of a pharmacological target for genioglossus reactivation throughout sleep. Int J Neuropsychopharmacol 37 41. PMID: 24470694.
Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. J Neuroimmune Pharmacol 17 1943. PMID: 24485144.
Garzón et al (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Mol Pain 5 11. PMID: 19284549.
Do you know of a great paper that uses (R)-(+)-Methanandamide (in Tocrisolve™ 100) from Tocris? If so please let us know.
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Keywords: (R)-(+)-Methanandamide (in TocrisolveTM 100), supplier, Potent, selective, CB1, agonists, water-soluble, emulsion, cannabinoids, Receptors, cb1r, TocrisolveTM100, Tocris Bioscience, CB1 Receptor Agonist products
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