Cat. No. 1780
Chemical Name: 8-(1-Naphthalenylmethyl)-4-oxo-1-ph
Biological ActivityPotent non-peptide agonist for the NOP receptor (EC50 = 305 nM, Ki = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Thomsen and Hohlweg (2000) (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br.J.Pharmacol. 131 903. PMID: 11053209.
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Citations are publications that use Tocris products. Selected citations for NNC 63-0532 include:
Gear et al (2014) NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience 257 139. PMID: 24188792.
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Keywords: NNC 63-0532, supplier, Potent, non-peptide, NOP, agonists, brain, penetrant, Nociceptin, Receptors, ORL1, OP4, Opioid, NNC630532, Tocris Bioscience, NOP Receptor Agonist products
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