NNC 711

Cat. No. 1779

NNC 711 C21H22N2O3.HCl [145645-62-1]

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Chemical Name: 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride

Biological Activity

Potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo. Also exhibits cognition-enhancing activity.

Technical Data

M.Wt:
386.88
Formula:
C21H22N2O3.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
145645-62-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

O'Connell et al (2001) Anti-ischemic and cognition-enhancing properties of NNC-711, a γ-aminobutyric acid reuptake inhibitor. Eur.J.Pharmacol. 424 37. PMID: 11470258.

Borden et al (1994) Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219. PMID: 7851497.

Suzdak et al (1992) NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: pharmacological characterization. Eur.J.Pharmacol. 224 189. PMID: 1468507.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for NNC 711 include:

Kersanté et al (2013) A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. Anesthesiology 591 2429. PMID: 23381899.

Samoudi et al (2012) Noisy galvanic vestibular stimulation promotes GABA release in the substantia nigra and improves locomotion in hemiparkinsonian rats. PLoS One 7 e29308. PMID: 22238601.

Yoshizumi et al (2012) Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Pain 116 1347. PMID: 22487864.

Héja et al (2009) Glutamate uptake triggers transporter-mediated GABA release from astrocytes. J Physiol 4 e7153. PMID: 19777062.

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Keywords: NNC 711, supplier, Selective, inhibitors, inhibits, GAT-1, GABA, Transporters, Monoamine, Neurotransmitter, NNC711, Tocris Bioscience, GABA Inhibitor products

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