Dynamin inhibitory peptide, myristoylated (control)

Cat. No. 1776

Dynamin inhibitory peptide, myristoylated (control) Myr-Gln-Pro-Pro-Ala-Ser-Asn-Pro-Arg-Val-Arg-NH2

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Biological Activity

Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775), an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant effect on GABAA receptor-mediated miniature IPSPs.

Technical Data

M.Wt:
1330.64
Formula:
C61H107N19O14
Sequence:
QPPASNPRVR

(Modifications: Gln-1 = Myr-Gln, Arg-10 = C-terminal amide)

Solubility:
Soluble to 0.67 mg/ml in 30% acetonitrile / water
Storage:
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302. PMID: 12646920.

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972. PMID: 11050117.

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419. PMID: 9148966.

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Keywords: Dynamin inhibitory peptide, myristoylated (control), supplier, 1775, Mitosis, Dynamin, Epac, GTPases, Tocris Bioscience, GTPase Inhibitor products

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