Cat. No. 1772
Chemical Name: 6-[[3-[4-(2-Methoxyphenyl)-1-pipera
Biological Activityα1-adrenoceptor antagonist and 5-HT1A receptor agonist (pIC50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kolassa et al (1989) Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil. Am.J.Cardiol. 64 7D. PMID: 2569265.
van Zwieten PA (1989) Pharmacologic profile of urapidil. Am.J.Cardiol. 64 1D. PMID: 2569262.
Gross et al (1987) Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for α1-adrenoceptor binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 336 597. PMID: 2832770.
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Keywords: Urapidil hydrochloride, supplier, 5-HT1A, agonists, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, α1-adrenergic, alpha1-adrenergic, a1-adrenergic, antagonists, Serotonin, Receptors, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products
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Selective, high affinity, non-competitive α1A adrenoceptor antagonist
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