S 14506 hydrochloride

Cat. No. 1771

S 14506 hydrochloride C24H26FN3O2.HCl [286369-38-8]

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Chemical Name: 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride

Biological Activity

Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.

Technical Data

M.Wt:
443.94
Formula:
C24H26FN3O2.HCl
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
286369-38-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Milligan et al (2001) S 14506: novel receptor coupling at 5-HT1A receptors. Neuropharmacology 40 334. PMID: 11166326.

Lima et al (1997) Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors. J.Neural Transm. 104 1059. PMID: 9503258.

Colpaert et al (1992) S 14506: a novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. Drug Dev.Res. 26 21.

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Keywords: S 14506 hydrochloride, supplier, potent, 5-HT1A, agonists, Serotonin, Receptors, S14506, hydrochloride, Tocris Bioscience, 5-HT1A Receptor Agonist products

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