Deguelin

Cat. No. 1770

Deguelin C23H22O6 [522-17-8]

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Chemical Name: (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one

Biological Activity

Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC50 values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo.

Technical Data

M.Wt:
394.42
Formula:
C23H22O6
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
522-17-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chun et al (2003) Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J.Natl.Cancer Inst. 95 291. PMID: 12591985.

Fang and Casida (1998) Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc.Natl.Acad.Sci.U.S.A. 95 3380. PMID: 9520374.

Udeani et al (1997) Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res. 57 3424. PMID: 9270008.

Takatsuki et al (1969) Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses. Appl.Microbiol. 18 660. PMID: 4312925.

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Citations are publications that use Tocris products. Selected citations for Deguelin include:

Hafeez et al (2016) BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. J Neurosci 11 e0145780. PMID: 26745145.

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Keywords: Deguelin, supplier, Anticancer, antiviral, agent, chemopreventive, proapoptotic, Apoptosis, Inducer, Tocris Bioscience, Apoptosis Inducing products

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