Flurbiprofen

Cat. No. 1769

Flurbiprofen C15H13FO2 [5104-49-4]

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Chemical Name: 2-Fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid

Biological Activity

Potent inhibitor of cyclooxygenase (IC50 values are 0.1 and 0.4 μM for inhibition of human COX-1 and COX-2 respectively). Analgesic, anti-inflammatory and antipyretic in vivo. Inhibits tumor cell growth in vitro and in vivo. Regulates prostate stem cell antigen through activation of Akt kinase. Also inhibits fibroblast proliferation in vitro.

Technical Data

M.Wt:
244.26
Formula:
C15H13FO2
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
5104-49-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Zemskova et al (2006) Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase. Biochem.Pharmacol. 72 1257. PMID: 16949054.

Hoferova et al (2002) The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma. Cancer Invest. 20 490. PMID: 12094544.

Gierse et al (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305 479. PMID: 7832763.

Glenn et al (1973) The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions 3 210. PMID: 4776365.

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Keywords: Flurbiprofen, supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxidase, Oxygenases, Oxidases, stem, cells, Akt, kinases, Analgesics, anti-inflammatory, and, antipyretics, Tocris Bioscience, Cyclooxygenase Inhibitor products

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