Fumagillin

Cat. No. 1768

Fumagillin C26H34O7 [23110-15-8]

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Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester

Biological Activity

Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.

Technical Data

M.Wt:
458.55
Formula:
C26H34O7
Solubility:
Soluble to 3 mM in ethanol
Storage:
Store at -20°C
CAS No:
23110-15-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457. PMID: 11848509.

Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153. PMID: 9770455.

Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555. PMID: 1701033.

Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327. PMID: 4630977.

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Citations are publications that use Tocris products. Selected citations for Fumagillin include:

Palmer et al (2012) A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol 165 1891. PMID: 21943108.

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Keywords: Fumagillin, supplier, Methionine, aminopeptidase-2, inhibitors, Proteases, Proteinases, antiangiogenics, angiogenesis, antibiotics, Tocris Bioscience, Aminopeptidase Inhibitor products

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