Cat. No. 2669
Chemical Name: (N-(3'-Fluorophenyl)ethyl-4-azahexac
Biological ActivityHigh affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Liu et al (2007) Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects. Eur.J.Pharmacol. 555 37. PMID: 17113074.
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Keywords: TC 1, supplier, High, affinity, σ1, sigma1, ligands, Receptors, TC1, Tocris Bioscience, σ1 Receptor Ligand products