UBP 301

Cat. No. 1766

UBP 301 C15H14IN3O6 [569371-10-4]

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Chemical Name: (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid

Biological Activity

Potent kainate receptor antagonist (apparent Kd = 5.94 μM). Displays ~ 30-fold selectivity over AMPA receptors.

Technical Data

M.Wt:
459.2
Formula:
C15H14IN3O6
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
569371-10-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

More et al (2003) Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br.J.Pharmacol. 138 1093. PMID: 12684265.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for UBP 301 include:

Cassé et al (2012) Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci 32 5186. PMID: 22496564.

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Keywords: UBP 301, supplier, Kainate, receptor, antagonists, Glutamate, Receptors, iGluR, Ionotropic, UBP301, Tocris Bioscience, Kainate Receptor Antagonist products

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