UBP 282

Cat. No. 1765

UBP 282 C15H15N3O6 [544697-47-4]

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Alternative Name: 3-CBW

Chemical Name: (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid

Biological Activity

AMPA and kainate receptor antagonist. Inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres.

Technical Data

M.Wt:
333.3
Formula:
C15H15N3O6
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 25 mM in 1eq. HCl
Purity:
>98 %
Storage:
Store at RT
CAS No:
544697-47-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

More et al (2003) Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br.J.Pharmacol. 138 1093. PMID: 12684265.

More et al (2002) The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres. Br.J.Pharmacol. 137 1125. PMID: 12429586.

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Keywords: UBP 282, supplier, AMPA/kainate, antagonists, receptors, Glutamate, AMPA, iGluR, Ionotropic, Kainate, UBP282, 3CBW, Tocris Bioscience, AMPA Receptor Antagonist products

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