Cat. No. 1764
Biological ActivityBioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Todd et al (2010) The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J.Neurosci. 30 7369. PMID: 20505104.
Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.U.S.A. 104 20588. PMID: 18077343.
Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547. PMID: 12500972.
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Keywords: Hemopressin (rat), supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, Tocris Bioscience, CB1 Receptor Antagonist products