Hemopressin (rat)

Cat. No. 1764

Hemopressin (rat) Pro-Val-Asn-Phe-Lys-Phe-Leu-Ser-His

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Biological Activity

Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.

Technical Data

M.Wt:
1088.27
Formula:
C53H77N13O12
Sequence:
PVNFKFLSH
Solubility:
Soluble to 2 mg/ml in 20% acetonitrile
Storage:
Desiccate at -20°C
CAS No:
568588-77-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Todd et al (2010) The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J.Neurosci. 30 7369. PMID: 20505104.

Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.U.S.A. 104 20588. PMID: 18077343.

Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547. PMID: 12500972.

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Keywords: Hemopressin (rat), supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, Tocris Bioscience, CB1 Receptor Antagonist products

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