Cat. No. 1763
Biological ActivityEndogenous peptide fragment that is a selective agonist for the sensory neuron specific receptor (EC50 values are 28 and 14 nM for SNSR3 and SNSR4 respectively); first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chen and Ikeda (2004) Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. J.Neurosci. 24 5044. PMID: 15163697.
Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 5 201. PMID: 11850634.
Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185. PMID: 11865303.
If you know of a relevant reference for BAM (8-22) please let us know.
Citations are publications that use Tocris products. Selected citations for BAM (8-22) include:
Hin et al (2014) Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorg Med Chem 22 5831. PMID: 25288495.
Moser and Giesler (2013) Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J Neurosci 33 6093. PMID: 23554490.
Do you know of a great paper that uses BAM (8-22) from Tocris? If so please let us know.
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Keywords: BAM (8-22), supplier, Selective, agonists, sensory, neuron-specific, receptors, SNSR, Tocris Bioscience, Sensory Neuron-Specific Receptor Agonist products
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