Cat. No. 1762
Alternative Name: AY 25712
Chemical Name: 4,5-Dihydro-5-methyl-4-oxo-5-phenyl
Biological ActivityHypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50 values are 1.3 and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jung et al (2007) Analogues of acrifan: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J.Med.Chem. 50 1445. PMID: 17358052.
Wise et al (2003) Molecular identification of high and low affinity receptors for nicotinic acid. J.Biol.Chem. 278 9869. PMID: 12522134.
Cayen et al (1982) Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis 45 267. PMID: 6818976.
Jirkovsky and Cayen (1982) Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. J.Med.Chem. 25 1154. PMID: 7143351.
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Keywords: Acifran, supplier, Hypolipidemic, agent, agonists, GPR109A, HM74A, GPR109B, receptors, HM74, nicotinic, acid, AY25712, Tocris Bioscience, Hydroxycarboxylic Acid Receptor Agonist products
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