Cat. No. 1762
Alternative Name: AY 25712
Chemical Name: 4,5-Dihydro-5-methyl-4-oxo-5-phenyl
Biological ActivityHypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50 values are 1.3 and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jung et al (2007) Analogues of acrifan: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J.Med.Chem. 50 1445. PMID: 17358052.
Wise et al (2003) Molecular identification of high and low affinity receptors for nicotinic acid. J.Biol.Chem. 278 9869. PMID: 12522134.
Cayen et al (1982) Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis 45 267. PMID: 6818976.
Jirkovsky and Cayen (1982) Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. J.Med.Chem. 25 1154. PMID: 7143351.
If you know of a relevant reference for Acifran please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Acifran from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Acifran, supplier, Hypolipidemic, agent, agonists, GPR109A, HM74A, GPR109B, receptors, HM74, nicotinic, acid, AY25712, Tocris Bioscience, Hydroxycarboxylic Acid Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Highly potent GPR183 (EBI2) agonistAR-C 69931 tetrasodium salt
Highly potent P2Y12 antagonistFTY 720
Potent S1P receptor agonist; also immunosuppressantCinacalcet hydrochloride
Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailableAMG 837 hemicalcium salt
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligandAZD 1283
High affinity P2Y12 antagonistEx 26
Potent and selective S1P1 receptor antagonist
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for Neuroscience 2017.