Cat. No. 2876
Chemical Name: (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a
Biological ActivityChemosensitizing agent; selectively reverses BCRP-mediated multidrug resistance to mitoxantrone (Cat. No. 4250), doxorubicin (Cat. No. 2252) and topotecan (Cat. No. 4562) in transfected MCF-7 cells. Does not reverse resistance in P-gp- or MRP-positive cells. Analog (Ko 143, Cat. No. 3241) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Rabindran et al (2000) Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 60 (47). PMID: 10646850.
Rabindran et al (1998) Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res. 58 5850. PMID: 9865745.
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Keywords: Fumitremorgin C, supplier, mycotoxins, chemosensitisers, chemosensitizers, chemosensitizing, chemosensitising, BCRP, breast, cancer, resistance, proteins, reverses, multidrug, resistance, MDR, FumitremorginC, Tocris Bioscience, Multidrug Transporter Inhibitor products