Fumitremorgin C

Cat. No. 2876

Fumitremorgin C C22H25N3O3 [118974-02-0]

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Chemical Name: (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione

Biological Activity

Chemosensitizing agent; selectively reverses BCRP-mediated multidrug resistance to mitoxantrone (Cat. No. 4250), doxorubicin (Cat. No. 2252) and topotecan (Cat. No. 4562) in transfected MCF-7 cells. Does not reverse resistance in P-gp- or MRP-positive cells. Analog (Ko 143, Cat. No. 3241) also available.

Technical Data

M.Wt:
379.45
Formula:
C22H25N3O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
118974-02-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Rabindran et al (2000) Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 60 (47). PMID: 10646850.

Rabindran et al (1998) Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res. 58 5850. PMID: 9865745.

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Keywords: Fumitremorgin C, supplier, mycotoxins, chemosensitisers, chemosensitizers, chemosensitizing, chemosensitising, BCRP, breast, cancer, resistance, proteins, reverses, multidrug, resistance, MDR, FumitremorginC, Tocris Bioscience, Multidrug Transporter Inhibitor products

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