Cat. No. 1761

Baicalein C15H10O5 [491-67-8]

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Chemical Name: 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one

Biological Activity

Inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation.

Technical Data

Soluble to 50 mM in DMSO
>98 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hsieh et al (2007) Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. Clin.Mol.Allergy 26 5. PMID: 18039391.

Nakahata et al (2003) Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Eur.J.Pharmacol. 461 1. PMID: 12568909.

Hsu et al (2001) Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur.J.Pharmacol. 425 165. PMID: 11513834.

Sekiya and Okuda (1982) Selective inhibition of platelet lipoxygenase by baicalein. Biochem.Biophys.Res.Commun. 105 1090. PMID: 6807310.

If you know of a relevant reference for Baicalein please let us know.

Citations are publications that use Tocris products. Selected citations for Baicalein include:

Maskrey et al (2014) 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition. PLoS One 11 33. PMID: 25349537.

Potapova et al (2013) Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. PLoS One 8 e73929. PMID: 24069252.

Gibson et al (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57 746. PMID: 18341994.

Do you know of a great paper that uses Baicalein from Tocris? If so please let us know.

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Keywords: Baicalein, supplier, Induces, G1, G2, cell, cycle, arrest, lipoxygenase, inhibitors, inhibits, 5-Lipoxygenase, platelet, 12-Lipoxygenase, Cell, Cycle, Lipoxygenase, Oxygenases, Oxidases, 5-LOX, 12-LOX, Tocris Bioscience, Lipoxygenase Inhibitor products

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