Nilutamide

Cat. No. 1759

Nilutamide C12H10F3N3O4 [63612-50-0]

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Alternative Name: RU 23908

Chemical Name: 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione

Biological Activity

Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active.

Technical Data

M.Wt:
317.22
Formula:
C12H10F3N3O4
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
63612-50-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ayub and Levell (1987) Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. J.Steroid Biochem. 28 43. PMID: 2956461.

Raynaud et al (1985) Pharmacology and clinical studies with RU 23908 (Anandron). Prog.Clin.Biol.Res. 185A 99. PMID: 4034583.

Raynaud et al (1984) The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer. The Prostate 5 299. PMID: 6374639.

Raynaud et al (1979) Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues. J.Steroid Biochem. 11 93. PMID: 385986.

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Keywords: Nilutamide, supplier, Androgen, receptor, antagonists, Orally, active, Dihydrotestosterone, Receptors, RU23908, chemotherapeutics, Tocris Bioscience, Androgen Receptor Antagonist products

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