PETCM

Cat. No. 1758

PETCM C8H8Cl3NO [10129-56-3]

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Chemical Name: α-(Trichloromethyl)-4-pyridineethanol

Biological Activity

Caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.

Technical Data

M.Wt:
240.52
Formula:
C8H8Cl3NO
Solubility:
Soluble to 50 mM in 1eq. HCl
Purity:
>99 %
Storage:
Store at RT
CAS No:
10129-56-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Jiang et al (2003) Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science 299 223. PMID: 12522243.

Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.U.S.A. 100 7533. PMID: 12808146.

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Keywords: PETCM, supplier, activators, caspase-3, Caspases, Proteinases, Proteases, Tocris Bioscience, Caspase Activator products

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