Cat. No. 1758
Chemical Name: α-(Trichloromethyl)-4-pyridineethano
Biological ActivityCaspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Jiang et al (2003) Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science 299 223. PMID: 12522243.
Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.U.S.A. 100 7533. PMID: 12808146.
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Keywords: PETCM, supplier, activators, caspase-3, Caspases, Proteinases, Proteases, Tocris Bioscience, Caspase Activator products
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