ALX 5407 hydrochloride
Cat. No. 1757
Alternative Name: (+)-NFPS
Chemical Name: N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-
Biological ActivitySelective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM).
Licensing InformationSold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use only
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. Psychopharmacology 179 54. PMID: 15759151.
Atkinson et al (2001) ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol.Pharmacol. 60 1414. PMID: 11723250.
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Citations are publications that use Tocris products. Selected citations for ALX 5407 hydrochloride include:
Yue et al (2016) Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity. Nat.Commun. 7 13501. PMID: 27874011.
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