ALX 5407 hydrochloride

Cat. No. 1757

ALX 5407 hydrochloride C24H24FNO3.HCl [200006-08-2]

Price and Availability

For ALX 5407 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: (+)-NFPS

Chemical Name: N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride

Biological Activity

Selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM).

Licensing Information

Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use only

Technical Data

M.Wt:
429.92
Formula:
C24H24FNO3.HCl
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
200006-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. Psychopharmacology 179 54. PMID: 15759151.

Atkinson et al (2001) ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol.Pharmacol. 60 1414. PMID: 11723250.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ALX 5407 hydrochloride include:

Yue et al (2016) Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity. Nat.Commun. 7 13501. PMID: 27874011.

Do you know of a great paper that uses ALX 5407 hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: ALX 5407 hydrochloride, supplier, Selective, non-transportable, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, ALX5407, hydrochloride, Tocris Bioscience, Glycine Transporter Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

New Products in this Area

Org 24598

Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.