Cat. No. 1748
Alternative Names: Z-LLL-al, Z-Leu-Leu-Leu-CHO
Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-leucy
Biological ActivityPotent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM). Inhibits TNF-α-induced NF-κB activation and IκBα degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Banerjee and Liefshitz (2001) Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. 21 3941. PMID: 11911275.
Tsubuki et al (1996) Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine. J.Biochem. 119 572. PMID: 8830056.
Palombella et al (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78 773. PMID: 8087845.
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Citations are publications that use Tocris products. Selected citations for MG 132 include:
Rivera-Pagán et al (2015) Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia. PLoS One 10 e0125195. PMID: 25886567.
Tamura et al (2015) A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset. Biol Open 4 155. PMID: 25596275.
Bhatnagar et al (2014) Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. J Biol Chem 289 25276. PMID: 25002582.
Chou et al (2014) Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development. J Immunol 193 1162. PMID: 24981454.
Choubey et al (2014) BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy 10 1105. PMID: 24879156.
Duellman et al (2014) Single nucleotide polymorphism-specific regulation of matrix metalloproteinase-9 by multiple miRNAs targeting the coding exon. Nucleic Acids Res 42 5518. PMID: 24627221.
Estève et al (2014) Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. J Biol Chem 289 8277. PMID: 24492612.
Luo et al (2013) Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I. J Immunol 191 660. PMID: 23772026.
Purnell and Fox (2013) Autophagy-mediated turnover of dynamin-related protein 1. BMC Neurosci 14 86. PMID: 23937156.
Ren et al (2013) A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory. Neuropsychopharmacology 38 778. PMID: 23303053.
Shrestha and Draviam (2013) Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr Biol 23 1514. PMID: 23891108.
Stec et al (2013) Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms. Mol Biol Cell 24 3000. PMID: 23885117.
Wiseman et al (2013) Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase. J Biol Chem 288 17803. PMID: 23640883.
Tran and Polakis (2012) Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex. J Biol Chem 287 28552. PMID: 22761442.
Wiech et al (2012) Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2. PLoS One 7 e51426. PMID: 23251530.
Vuolteenaho et al (2009) Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediators Inflamm 2009 345838. PMID: 19688109.
Huang et al (2008) Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation. Oncogene 27 2422. PMID: 17952113.
Sareila et al (2008) Effects of levo- and dextrosimendan on NF-kappaB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli. Br J Pharmacol 155 884. PMID: 19002103.
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Keywords: MG 132, supplier, Proteasome, calpain, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, MG132, anticancer, Tocris Bioscience, Proteasome Inhibitor products
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