Isoproterenol hydrochloride

Cat. No. 1747

Isoproterenol hydrochloride C11H17NO3.HCl [51-30-9]

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Alternative Name: Isoprenaline

Chemical Name: 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride

Biological Activity

Standard selective β-adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo. Also available as part of the β-Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™.

Technical Data

M.Wt:
247.72
Formula:
C11H17NO3.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>97 %
Storage:
Store at RT
CAS No:
51-30-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Akimoto et al (2002) Nitric oxide (NO) primarily accounts for endothelium-dependent component of β-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline. J.Smooth Muscle Res. 38 87. PMID: 12596888.

Schmitt and Stork (2000) β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf. J.Biol.Chem. 275 25342. PMID: 10840035.

Lotti et al (1982) Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment. J.Auton.Pharmacol. 2 169. PMID: 6292228.

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Citations are publications that use Tocris products. Selected citations for Isoproterenol hydrochloride include:

Hansen and Manahan-Vaughan (2015) Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of β-Adrenergic Receptors. Eur J Neurosci 25 1889. PMID: 24464942.

Lang et al (2015) Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart. Cereb Cortex 8 409. PMID: 25673629.

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. J Mol Cell Cardiol 10 e0132884. PMID: 26222156.

Siuda et al (2015) Optodynamic simulation of β-adrenergic receptor signalling. Circ Arrhythm Electrophysiol 6 8480. PMID: 26412387.

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661. PMID: 26030448.

Sun et al (2015) Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling. Nat Commun 5 15950. PMID: 26516061.

Gray et al (2014) Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. Biochem Biophys Res Commun 289 14600. PMID: 24706758.

Yang et al (2014) PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling. Diabetes 66 83. PMID: 24225179.

Santulli et al (2012) Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor. J Cell Biol 61 692. PMID: 22315324.

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474. PMID: 22164209.

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842. PMID: 21828176.

Duncan et al (2010) The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors. J Biol Chem 31 1646. PMID: 20525077.

Maehashi et al (2008) Bitter peptides activate hTAS2Rs, the human bitter receptors. PLoS One 365 851. PMID: 18037373.

Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Sci Rep 24 7745. PMID: 15342742.

Do you know of a great paper that uses Isoproterenol hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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