Isoproterenol hydrochloride

Cat. No. 1747

Isoproterenol hydrochloride C11H17NO3.HCl [51-30-9]

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Alternative Name: Isoprenaline

Chemical Name: 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride

Biological Activity

Standard selective β-adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo. Also available as part of the β-Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™.

Technical Data

M.Wt:
247.72
Formula:
C11H17NO3.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>97 %
Storage:
Store at RT
CAS No:
51-30-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Akimoto et al (2002) Nitric oxide (NO) primarily accounts for endothelium-dependent component of β-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline. J.Smooth Muscle Res. 38 87. PMID: 12596888.

Schmitt and Stork (2000) β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf. J.Biol.Chem. 275 25342. PMID: 10840035.

Lotti et al (1982) Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment. J.Auton.Pharmacol. 2 169. PMID: 6292228.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Isoproterenol hydrochloride include:

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661. PMID: 26030448.

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474. PMID: 22164209.

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842. PMID: 21828176.

Do you know of a great paper that uses Isoproterenol hydrochloride from Tocris? If so please let us know.

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Keywords: Isoproterenol hydrochloride, supplier, selective, β-adrenoceptor, beta-adrenoceptor, b-adrenoceptor, β-adrenergic, beta-adrenergic, b-adrenergic, agonists, Receptors, Non-Selective, Tocris Bioscience, Non-selective Adrenergic β Receptor Agonist products

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