Cat. No. 1745
Chemical Name: 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrol
Biological ActivityPotent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 μM and 15 μM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Williams-Karnesky et al (2013) Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J.Clin.Invest. 123 3552. PMID: 23863710.
Ugarkar et al (2000) Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J.Med.Chem. 43 2883. PMID: 10956196.
Parkinson and Geiger (1996) Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells. J.Pharmacol.Exp.Ther. 277 1397. PMID: 8667202.
Massillon et al (1994) Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem.J. 299 123. PMID: 8166629.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for 5-Iodotubercidin include:
Rüben et al (2015) Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors. PLoS One 10 e0132453. PMID: 26192590.
Visentin et al (2012) Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate. Mol Pharmacol 82 209. PMID: 22554803.
Fassett et al (2011) Adenosine kinase regulation of cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol 300 H1722. PMID: 21335462.
Do you know of a great paper that uses 5-Iodotubercidin from Tocris? If so please let us know.
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Keywords: 5-Iodotubercidin, supplier, Potent, adenosines, kinase, inhibitors, nucleoside, transporters, ENT1, reuptake, Purine, Transporters, Pyrimidine, Equilibrative, Monoamine, Neurotransmitter, ADK, 5-it, inhibits, DNA, methylation, Tocris Bioscience, Adeonsine Kinase Inhibitor products
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