Tropisetron hydrochloride

Cat. No. 2459

Tropisetron hydrochloride C17H20N2O2.HCl [105826-92-4]

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Alternative Names: Novaban, ICS 205930

Chemical Name: (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride

Biological Activity

Potent, orally active 5-HT3 receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR.

Technical Data

Soluble to 100 mM in water and to 50 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mhatre et al (2004) 5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake. Eur.J.Pharmacol. 491 149. PMID: 15140631.

Papke et al (2004) Activity of α7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. Bioorg.Med.Chem.Lett. 14 1849. PMID: 15050614.

Middlemiss and Tricklebank (1992) Centrally active 5-HT receptor agonists and antagonists. Neurosci.Biobehav.Rev. 16 75. PMID: 1553108.

Seynaeve et al (1991) 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granisetron and tropisetron. Anticancer Drugs 2 343. PMID: 1665723.

If you know of a relevant reference for Tropisetron hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Tropisetron hydrochloride include:

Johnson et al (2015) Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism. Proc Natl Acad Sci U S A 207 48. PMID: 25543027.

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Respir Physiol Neurobiol 7 2336. PMID: 26114334.

Sendin et al (2014) Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea. Mol Cell Biol 111 1999. PMID: 24429348.

Spilman et al (2014) The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res 1551 25. PMID: 24389031.

Do you know of a great paper that uses Tropisetron hydrochloride from Tocris? If so please let us all ▼show less ▲

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Keywords: Tropisetron hydrochloride, supplier, Potent, 5-HT3, receptor, antagonists, orally, active, Serotonin, Receptors, ICS205930, Nicotinics, nAChRs, alpha7, a7, α7, partial, agonists, Tocris Bioscience, 5-HT3 Receptor Antagonist products

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5-HT Scientific Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

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