Cat. No. 0682

L-690,488 C32H52O16P2 [142523-14-6]

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Chemical Name: 1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)]-2,2-dimethylpropanoate

Biological Activity

Cell-permeable prodrug of the potent inositol monophosphatase inhibitor L-690,330 (Cat. No. 0681); penetrates cells more effectively than its metabolite.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in DMSO
>98 %
Store at -80°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chen et al (1998) Stimulatory effect of lithium on glucose transport in rat adipocytes is not mediated by elevation of IP1. Am.J.Physiol. 275 E272. PMID: 9688629.

Atack et al (1994) Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J.Pharmacol.Exp.Ther. 270 70. PMID: 8035344.

If you know of a relevant reference for L-690,488 please let us know.

Citations are publications that use Tocris products. Selected citations for L-690,488 include:

Harding et al (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Mol Cancer 81 4261. PMID: 24002062.

Do you know of a great paper that uses L-690,488 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: L-690,488, supplier, Inositol, monophosphatase, inhibitors, inhibits, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690488, Tocris Bioscience, Inositol Phosphatase products

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