Reserpine

Cat. No. 2742

Reserpine C33H40N2O9 [50-55-5]

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Chemical Name: (3β,16β,17α,18β,20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester

Biological Activity

Binds the vesicular monoamine transporter (VMAT2) and inhibits transport of biogenic amines into adrenal chromaffin granules and synaptic vesicles. Causes depletion of biogenic amine stores. Antihypertensive and antipsychotic.

Technical Data

M.Wt:
608.68
Formula:
C33H40N2O9
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
50-55-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Metzger et al (2002) Inhibitory effect of reserpine on dopamine transporter function. Eur.J.Pharmacol. 456 39. PMID: 12450567.

Heslop and Curzon (1999) Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes. Neuropharmacology 38 883. PMID: 10465692.

Schuldiner et al (1993) Reserpine binding to a vesicular amine transporter expressed in chinese hamster ovary fibroblasts. J.Biol.Chem. 268 29. PMID: 8416935.

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