CL 218872

Cat. No. 1709

CL 218872 C13H9F3N4 [66548-69-4]

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Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Biological Activity

Benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Technical Data

Soluble to 50 mM in DMSO and to 25 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Sieghart (1995) Structure and pharmacology of γ-aminobutyric acidA receptor subtypes. Pharmacol.Rev. 47 181. PMID: 7568326.

Lippa et al (1979) Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 10 831. PMID: 40258.

Squires et al (1979) Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 10 825. PMID: 40257.

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Keywords: CL 218872, supplier, Benzodiazepine, agonists, GABAA, Receptors, CL218872, Tocris Bioscience, GABAA Receptor Benzodiazepine products

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