Cat. No. 1708
Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-met
Biological ActivityCyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Palomer et al (2002) Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 45 1402. PMID: 11906281.
Shen and Winter (1977) Chemical and biological studies on indomethacin, sulindac and their analogs. Adv.Drug Res. 12 90. PMID: 343530.
Walters and Willoughby (1965) Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 90 641. PMID: 5849618.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Indomethacin include:
Gonnermann et al (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. Oncoimmunology 4 e988460. PMID: 25949900.
Tang et al (2014) Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun 5 3284. PMID: 24518663.
Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190. PMID: 22517902.
Miller et al (2012) CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A 109 20602. PMID: 23185004.
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Keywords: Indomethacin, supplier, Cyclooxygenase, inhibitors, COX-1, COX-2, Oxygenases, Oxidases, Tocris Bioscience, Cyclooxygenase Inhibitor products
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