Sulindac

Cat. No. 1707

Sulindac C20H17FO3S [38194-50-2]

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Chemical Name: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid

Biological Activity

Prodrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo. Widely used anti-inflammatory agent.

Technical Data

M.Wt:
356.41
Formula:
C20H17FO3S
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
38194-50-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Haanen (2001) Sulindac and its derivatives: a novel class of anticancer agents. Curr.Opin.Investig.Drugs 2 677. PMID: 11569947.

Taylor et al (2000) Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Res. 60 6607. PMID: 11118042.

Shen and Winter (1977) Chemical and biological studies on indomethacin, sulindac and their analogs. Adv.Drug Res. 12 90. PMID: 343530.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Sulindac include:

Hagen et al (2015) Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells 4 84. PMID: 25679284.

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Keywords: Sulindac, supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxygenases, Oxidases, Tocris Bioscience, Cyclooxygenase Inhibitor products

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